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Mendelian randomisa...
Mendelian randomisation study of the relationship between vitamin D and risk of glioma
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Takahashi, Hannah (author)
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Cornish, Alex J. (author)
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Sud, Amit (author)
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show more...
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Law, Philip J. (author)
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Kinnersley, Ben (author)
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Ostrom, Quinn T. (author)
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Labreche, Karim (author)
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Eckel-Passow, Jeanette E. (author)
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Armstrong, Georgina N. (author)
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Claus, Elizabeth B. (author)
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Il'yasova, Dora (author)
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Schildkraut, Joellen (author)
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Barnholtz-Sloan, Jill S. (author)
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Olson, Sara H. (author)
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Bernstein, Jonine L. (author)
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Lai, Rose K. (author)
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Schoemaker, Minouk J. (author)
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Simon, Matthias (author)
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Hoffmann, Per (author)
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Nöthen, Markus M. (author)
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Joeckel, Karl-Heinz (author)
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Chanock, Stephen (author)
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Rajaraman, Preetha (author)
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Johansen, Christoffer (author)
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Jenkins, Robert B. (author)
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Melin, Beatrice S. (author)
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Wrensch, Margaret R. (author)
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Sanson, Marc (author)
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Bondy, Melissa L. (author)
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Turnbull, Clare (author)
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Houlston, Richard S. (author)
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(publisher)
- Nature Publishing Group 2018
- 2018
- English.
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In: Scientific Reports. - 2045-2322. ; 8
Abstract
Subject headings
Close
- To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH) D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH) D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for 25(OH) D levels with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighted (IVW) and maximum likelihood estimation (MLE) methods. A non-significant association between 25(OH) D levels and glioma risk was shown using both the IVW (OR = 1.21, 95% confidence interval [CI] = 0.90-1.62, P = 0.201) and MLE (OR = 1.20, 95% CI = 0.98-1.48, P = 0.083) methods. In an exploratory analysis of tumour subtype, an inverse relationship between 25(OH)D levels and glioblastoma (GBM) risk was identified using the MLE method (OR = 0.62, 95% CI = 0.43-0.89, P = 0.010), but not the IVW method (OR = 0.62, 95% CI = 0.37-1.04, P = 0.070). No statistically significant association was shown between 25(OH) D levels and non-GBM glioma. Our results do not provide evidence for a causal relationship between 25(OH) D levels and all forms of glioma risk. More evidence is required to explore the relationship between 25(OH) D levels and risk of GBM.
Subject headings
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Occupational Health and Environmental Health (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Arbetsmedicin och miljömedicin (hsv)
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Medical Genetics (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska och farmaceutiska grundvetenskaper (hsv)
- Medicinsk genetik (hsv)
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cancer and Oncology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Cancer och onkologi (hsv)
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- By the author/editor
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Takahashi, Hanna ...
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Cornish, Alex J.
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Sud, Amit
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Law, Philip J.
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Kinnersley, Ben
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Ostrom, Quinn T.
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show more...
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Labreche, Karim
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Eckel-Passow, Je ...
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Armstrong, Georg ...
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Claus, Elizabeth ...
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Il'yasova, Dora
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Schildkraut, Joe ...
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Barnholtz-Sloan, ...
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Olson, Sara H.
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Bernstein, Jonin ...
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Lai, Rose K.
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Schoemaker, Mino ...
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Simon, Matthias
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Hoffmann, Per
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Nöthen, Markus M ...
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Joeckel, Karl-He ...
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Chanock, Stephen
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Rajaraman, Preet ...
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Johansen, Christ ...
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Jenkins, Robert ...
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Melin, Beatrice ...
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Wrensch, Margare ...
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Sanson, Marc
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Bondy, Melissa L ...
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Turnbull, Clare
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Houlston, Richar ...
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